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Citation Information

Type Journal Article - Public health action
Title Tuberculosis case burden and treatment outcomes in children, adults and older adults, Vanuatu, 2007--2011
Author(s)
Volume 4
Issue 1
Publication (Day/Month/Year) 2014
Page numbers S14-S18
URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547594/
Abstract
Setting: All five DOTS centres in Vanuatu.

Objectives: To determine across the age spectrum the tuberculosis (TB) case burden, disease pattern and treatment outcomes in patients registered between 2007 and 2011.

Design: Retrospective cohort study involving reviews of TB registers and treatment cards.

Results: Of 588 TB patients, 142 (24%) were children (aged 0–14 years), 327 (56%) adults (aged 15–54 years) and 119 (20%) were older adults (aged ⩾55 years; subdivided into 55–64 and ⩾65 years); 568 were new patients, 13 had been treated previously and 7 had unknown status. Compared with adults, children with new TB had a higher prevalence of extra-pulmonary TB (75% vs. 34%, OR 5.7, 95%CI 3.6–9.0) and a lower prevalence of smear-positive pulmonary TB (11% vs. 45%, OR 0.15, 95%CI 0.1–0.3), while older adults with new TB had a higher prevalence of smear-negative pulmonary TB (38% vs. 21%, OR 2.4, 95%CI 1.5–3.8). Overall TB treatment success was 83%, but in the second category of older adults (⩾65 years) treatment success was 67% and case fatality was 18%.

Conclusion: Children and older adults constitute 45% of the TB burden in Vanuatu. Differences in disease patterns and poorer treatment outcomes in older adults have implications for policy and practice.

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